Population pharmacokinetics and individualized dosing of tigecycline for critically ill patients: a prospective study with intensive sampling.

ABSTRACT: Background: Due to the heterogeneity of critically ill patients, the pharmacokinetics of tigecycline are unclear, and the optimal dosing strategy is controversial. Methods: A single-center prospective clinical study that included critically ill patients who received tigecycline was performed. Blood samples were intensively sampled (eight samples each), and plasma drug concentrations were determined. A population pharmacokinetic (PPK) model was developed and evaluated by goodness-of-fit plots, bootstrap analysis and visual predictive checks. Monte Carlo simulation was conducted to optimize the dosage regimen. Results: Overall, 751 observations from 98 patients were included. The final PPK model was a two-compartment model incorporating covariates of creatinine clearance

SUBMITTER: Su W 

PROVIDER: S-EPMC10859475 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature