Tumor suppressive function of IGF2BP1 in gastric cancer through decreasing MYC.

ABSTRACT: Gastric cancer is one of the most common causes of cancer-related death worldwide. The N⁶ -methyladenosine (m⁶ A) reader IGF2BP1 (insulin-like growth factor-2 mRNA binding protein 1) has been reported to promote cancer progression by stabilizing oncogenic mRNAs through its m⁶ A-binding activity in some tumors. However, the role of IGF2BP1 in gastric carcinogenesis remains unclear. In this study, we found that IGF2BP1 is significantly downregulated in tumor tissues from patients with gastric cancer. Lower expression of IGF2BP1 is associated with poor prognosis. Gastric cancer cell proliferation is suppressed by IGF2BP1 in an m⁶ A-dependent manner. Additionally, IGF2BP1 is able to significantly attenuate tumor growth of gastric cancer cells. Furthe

SUBMITTER: Ding N 

PROVIDER: S-EPMC10859605 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature