New techniques to identify the tissue of origin for cancer of unknown primary in the era of precision medicine: progress and challenges.

ABSTRACT: Despite a standardized diagnostic examination, cancer of unknown primary (CUP) is a rare metastatic malignancy with an unidentified tissue of origin (TOO). Patients diagnosed with CUP are typically treated with empiric chemotherapy, although their prognosis is worse than those with metastatic cancer of a known origin. TOO identification of CUP has been employed in precision medicine, and subsequent site-specific therapy is clinically helpful. For example, molecular profiling, including genomic profiling, gene expression profiling, epigenetics and proteins, has facilitated TOO identification. Moreover, machine learning has improved identification accuracy, and non-invasive methods, such as liquid biopsy and image omics, are gaining momentum. However, the heterogeneity in prediction accuracy

SUBMITTER: Ma W 

PROVIDER: S-EPMC10859692 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature