Association of Genetic Variants with Postsurgical Pain: A Systematic Review and Meta-analyses.

ABSTRACT:

Background

Postsurgical pain is a key component of surgical recovery. However, the genetic drivers of postsurgical pain remain unclear. A broad review and meta-analyses of variants of interest will help investigators understand the potential effects of genetic variation.

Methods

This article is a systematic review of genetic variants associated with postsurgical pain in humans, assessing association with postsurgical pain scores and opioid use in both acute (0 to 48 h postoperatively) and chronic (at least 3 months postoperatively) settings. PubMed, Embase, and the Cochrane Central Register of Controlled Trials were searched from 2000 to 2022 for studies using search terms related to genetic variants and postsurgical pain in humans. English-language studies in adult patients

SUBMITTER: Frangakis SG 

PROVIDER: S-EPMC10859728 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature