Disentangling specific and unspecific components of innate immune memory in a copepod-tapeworm system.

ABSTRACT: Evidence that the innate immune system can respond with forms of memory upon reinfection has been accumulating over the past few years. These phenomena of "immune priming" in invertebrates, and "trained immunity" in vertebrates, are contrary to previous belief that immune memory and specificity are restricted to the adaptive immune system. However, while trained immunity is usually a response with rather low specificity, immune priming has shown highly specific responses in certain species. To date, it is largely unknown how specificity in innate immune memory can be achieved in response to different parasite types. Here, we revisited a system where an exceptionally high degree of innate immune specificity had been demonstrated for the first time, consisting of the copepod Macrocyclops

SUBMITTER: Ng TH 

PROVIDER: S-EPMC10859752 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature