Chronic hypoxia disrupts T regulatory cell phenotype contributing to the emergence of exTreg-T_H17 cells.

ABSTRACT: The imbalance between pro-inflammatory T helper 17 (T_H17) cells and anti-inflammatory regulatory T cells (Tregs) has been implicated in multiple inflammatory and autoimmune conditions, but the effects of chronic hypoxia (CH) on this balance have yet to be explored. CH-exposed mice have an increased prevalence of T_H17 cells in the lungs with no change in Tregs. This imbalance is significant because it precedes the development of pulmonary hypertension (PH), and T_H17 cells are a major contributor to CH-induced PH. While Tregs have been shown to attenuate or prevent the development of certain types of PH through activation and adoptive transfer experiments, why Tregs remain unable to prevent disease progression naturally, specifically in CH-induced PH, remains

SUBMITTER: Lantz BJ 

PROVIDER: S-EPMC10859758 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature