Single‑agent nintedanib suppresses metastatic osteosarcoma growth by inhibiting tumor vascular formation.

ABSTRACT: New therapeutic approaches are needed for osteosarcoma, which is the most common malignancy of the bone, especially for metastatic cases. Nintedanib is a potent, oral tyrosine kinase inhibitor approved for treating idiopathic pulmonary fibrosis, which blocks a variety of receptor signals, including fibroblast growth factor receptors, vascular endothelial growth factor receptors and platelet-derived growth factor receptors. The present study assessed the effect of nintedanib on previously developed mouse AXT osteosarcoma cells, and on AXT-derived osteosarcoma developed in C57BL/6 mice, which displays lethal tumors with osteoid formation and lung metastatic lesions that mimics human disease. In vitro analysis, including flow cytometry and immunoblotting, revealed that nintedanib inhib

SUBMITTER: Shimizu T 

PROVIDER: S-EPMC10859826 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature