Correlation between mismatch repair statuses and the prognosis of stage I-IV colorectal cancer.

ABSTRACT:

Background

The role of microsatellite instability (MSI) and prognosis for stage II-III colorectal cancer (CRC) has been described, but the role of MSI in stage I and IV CRC is controversial.

Methods

A total of 2,540 CRC patients were collected from Huzhou Central Hospital, China, from January 2006 to 2016, and 783 cases were excluded. This retrospective study illustrates the correlation between MMR status and prognosis for 1,757 CRC patients as well as the correlation between MSI and prognosis for CRC patients. Two groups were classified as MSI-H and MSI-L&MSS. If the expression of one or more mismatch repair (MMR) proteins was negative, it was considered as microsatellite instability high expression (MSI-H), whereas positive expression was considered as microsatellite insta

SUBMITTER: Tong G 

PROVIDER: S-EPMC10859923 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature