Assessing the effectiveness of the expanded hepatitis A vaccination program in China: an interrupted time series design.

ABSTRACT:

Introduction

China initialised the expanded hepatitis A vaccination programme (EHAP) in 2008. However, the effectiveness of the programme remains unclear. We aimed to comprehensively evaluate the effectiveness of EHAP in the country.

Methods

Based on the provincial data on the incidence of hepatitis A (HepA), the population and meteorological variables in China, we developed interrupted time series (ITS) models to estimate the effectiveness of EHAP with the autocorrelation, seasonality and the meteorological confounders being controlled. Results were also stratified by economic zones, age groups and provinces.

Results

We found a 0.9% reduction (RR=0.991, 95% CI: 0.990 to 0.991) in monthly HepA incidence after EHAP, which was 0.3% greater than the reduction rate before

SUBMITTER: Wu Y 

PROVIDER: S-EPMC10859990 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature