Design differences and variation in results between randomised trials and non-randomised emulations: meta-analysis of RCT-DUPLICATE data.

ABSTRACT:

Objective

To explore how design emulation and population differences relate to variation in results between randomised controlled trials (RCT) and non-randomised real world evidence (RWE) studies, based on the RCT-DUPLICATE initiative (Randomised, Controlled Trials Duplicated Using Prospective Longitudinal Insurance Claims: Applying Techniques of Epidemiology).

Design

Meta-analysis of RCT-DUPLICATE data.

Data sources

Trials included in RCT-DUPLICATE, a demonstration project that emulated 32 randomised controlled trials using three real world data sources: Optum Clinformatics Data Mart, 2004-19; IBM MarketScan, 2003-17; and subsets of Medicare parts A, B, and D, 2009-17.

Eligibility criteria for selecting studies

Trials where the primary analysis resulted in a h

SUBMITTER: Heyard R 

PROVIDER: S-EPMC10860009 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature