Dataset Information

PM₁₀ increases mortality risk in rheumatoid arthritis-associated interstitial lung disease.

ABSTRACT:

Objectives

The effect of air pollution on the prognosis of rheumatoid arthritis-associated interstitial lung disease (RA-ILD) remains poorly understood. We aimed to evaluate the effect of long-term exposure to particulate matter with an aerodynamic diameter of ≤10 µm (PM₁₀) and nitrogen dioxide (NO₂) on mortality in patients with RA-ILD.

Methods

We included 309 patients (mean age, 61.7 years; male, 44.3%) with RA-ILD. Individual-level long-term exposures to PM₁₀ and NO₂ at their residential addresses were estimated using a national-scale exposure prediction model. The effect of the two air pollutants on mortality was estimated using a Cox-proportional hazards model adjusted for individual-level and area-level characteristics.

Results

The median follow-up period was 4.8 years, and 40.8% of patients died or underwent lung transplantation. The annual average concentrations of PM₁₀ and NO₂ were 56.3 μg/m³ and 22.4 ppb, respectively. When air pollutant levels were stratified by quartiles, no association was observed between air pollutant concentration and mortality in patients with RA-ILD. However, when stratified by two groups (high exposure (top 25th percentile) vs low exposure (bottom 75th percentile)), we observed a significant association between high PM₁₀ exposure and mortality (HR 1.68; 95% CI 1.11 to 2.52; p=0.013) but no association between NO₂ exposure and mortality. In the subgroup analyses, the effect of high PM₁₀ exposure on mortality was significant in patients aged <65 years (HR 1.98; 95% CI 1.02 to 3.85; p=0.045).

Conclusions

Our results indicated that high PM₁₀ exposure may be associated with mortality in patients with RA-ILD.

SUBMITTER: Kim SH

PROVIDER: S-EPMC10860120 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature

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Publications

PM<sub>10</sub> increases mortality risk in rheumatoid arthritis-associated interstitial lung disease.

Kim Soo Han SH Kim Sun-Young SY Yoon Hee-Young HY Song Jin Woo JW

RMD open 20240208 1

<h4>Objectives</h4>The effect of air pollution on the prognosis of rheumatoid arthritis-associated interstitial lung disease (RA-ILD) remains poorly understood. We aimed to evaluate the effect of long-term exposure to particulate matter with an aerodynamic diameter of ≤10 µm (PM<sub>10</sub>) and nitrogen dioxide (NO<sub>2</sub>) on mortality in patients with RA-ILD.<h4>Methods</h4>We included 309 patients (mean age, 61.7 years; male, 44.3%) with RA-ILD. Individual-level long-term exposures to P ...[more]

PMID: 38331470

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Project description:ObjectivePatients at high risk of rheumatoid arthritis-associated interstitial lung disease (RA-ILD) would benefit from being identified before the onset of respiratory symptoms; this can be done by screening patients with the use of chest high-resolution computed tomography (HRCT). Our objective was to develop and validate a risk score for patients who have subclinical RA-ILD.MethodsOur study included a discovery population and a replication population from 2 prospective RA cohorts (ESPOIR and TRANSLATE2, respectively) without pulmonary symptoms who had received chest HRCT scans. All patients were genotyped for MUC5B rs35705950. After multiple logistic regression, a risk score based on independent risk factors for subclinical RA-ILD was developed in the discovery population and tested for validation in the replication population.ResultsThe discovery population included 163 patients with RA, and the replication population included 89 patients with RA. The prevalence of subclinical RA-ILD was 19.0% and 16.9%, respectively. In the discovery population, independent risk factors for subclinical RA-ILD were presence of the MUC5B rs35705950 T allele (odds ratio [OR] 3.74 [95% confidence interval (95% CI) 1.37, 10.39]), male sex (OR 3.93 [95% CI 1.40, 11.39]), older age at RA onset (for each year, OR 1.10 [95% CI 1.04, 1.16]), and increased mean Disease Activity Score in 28 joints using the erythrocyte sedimentation rate (for each unit, OR 2.03 [95% CI 1.24, 3.42]). We developed and validated a derived risk score with receiver operating characteristic areas under the curve of 0.82 (95% CI 0.70-0.94) for the discovery population and 0.78 (95% CI 0.65-0.92) for the replication population. Excluding MUC5B rs35705950 from the model provided a lower goodness of fit (likelihood ratio test, P = 0.01).ConclusionWe developed and validated a risk score that could help identify patients at high risk of subclinical RA-ILD. Our findings support an important contribution of MUC5B rs35705950 to subclinical RA-ILD risk.

Dataset Information

PM₁₀ increases mortality risk in rheumatoid arthritis-associated interstitial lung disease.

Objectives

Methods

Results

Conclusions

Publications

PM<sub>10</sub> increases mortality risk in rheumatoid arthritis-associated interstitial lung disease.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

PM10 increases mortality risk in rheumatoid arthritis-associated interstitial lung disease.

Objectives

Methods

Results

Conclusions

Publications

PM<sub>10</sub> increases mortality risk in rheumatoid arthritis-associated interstitial lung disease.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

PM₁₀ increases mortality risk in rheumatoid arthritis-associated interstitial lung disease.