Genetic models for lineage tracing in musculoskeletal development, injury, and healing.

ABSTRACT: Musculoskeletal development and later post-natal homeostasis are highly dynamic processes, marked by rapid structural and functional changes across very short periods of time. Adult anatomy and physiology are derived from pre-existing cellular and biochemical states. Consequently, these early developmental states guide and predict the future of the system as a whole. Tools have been developed to mark, trace, and follow specific cells and their progeny either from one developmental state to the next or between circumstances of health and disease. There are now many such technologies alongside a library of molecular markers which may be utilized in conjunction to allow for precise development of unique cell 'lineages'. In this review, we first describe the development of the musculoskeletal

SUBMITTER: Loder S 

PROVIDER: S-EPMC10860167 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature