Rapid protection against viral infections by chemokine-accelerated post-exposure vaccination.

ABSTRACT:

Introduction

Prophylactic vaccines generate strong and durable immunity to avoid future infections, whereas post-exposure vaccinations are intended to establish rapid protection against already ongoing infections. Antiviral cytotoxic CD8⁺ T cells (CTL) are activated by dendritic cells (DCs), which themselves must be activated by adjuvants to express costimulatory molecules and so-called signal 0-chemokines that attract naive CTL to the DCs.

Hypothesis

Here we asked whether a vaccination protocol that combines two adjuvants, a toll-like receptor ligand (TLR) and a natural killer T cell activator, to induce two signal 0 chemokines, synergistically accelerates CTL activation.

Methods

We used a well-characterized vaccination model based on the model antigen ova

SUBMITTER: Heine A 

PROVIDER: S-EPMC10860197 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature