High-fat and high-sucrose diet impairs female reproduction by altering ovarian transcriptomic and metabolic signatures.

ABSTRACT:

Background

Excessive energy intake in modern society has led to an epidemic surge in metabolic diseases, such as obesity and type 2 diabetes, posing profound threats to women's reproductive health. However, the precise impact and underlying pathogenesis of energy excess on female reproduction remain unclear.

Methods

We established an obese and hyperglycemic female mouse model induced by a high-fat and high-sucrose (HFHS) diet, then reproductive phenotypes of these mice were evaluated by examing sexual hormones, estrous cycles, and ovarian morphologies. Transcriptomic and precise metabolomic analyses of the ovaries were performed to compare the molecular and metabolic changes in HFHS mice. Finally, orthogonal partial least squares discriminant analysis was performed to compar

SUBMITTER: Liu C 

PROVIDER: S-EPMC10860219 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature