Horizontal gene transfer after faecal microbiota transplantation in adolescents with obesity.

ABSTRACT:

Background

Horizontal gene transfer (HGT) describes the transmission of DNA outside of direct ancestral lineages. The process is best characterised within the bacterial kingdom and can enable the acquisition of genetic traits that support bacterial adaptation to novel niches. The adaptation of bacteria to novel niches has particular relevance for faecal microbiota transplantation (FMT), a therapeutic procedure which aims to resolve gut-related health conditions of individuals, through transplanted gut microbiota from healthy donors.

Results

Three hundred eighty-one stool metagenomic samples from a placebo-controlled FMT trial for obese adolescents (the Gut Bugs Trial) were analysed for HGT, using two complementary methodologies. First, all putative HGT events, including hist

SUBMITTER: Behling AH 

PROVIDER: S-EPMC10860221 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature