Using tumor habitat-derived radiomic analysis during pretreatment ¹⁸F-FDG PET for predicting KRAS/NRAS/BRAF mutations in colorectal cancer.

ABSTRACT:

Background

To investigate the association between Kirsten rat sarcoma viral oncogene homolog (KRAS) / neuroblastoma rat sarcoma viral oncogene homolog (NRAS) /v-raf murine sarcoma viral oncogene homolog B (BRAF) mutations and the tumor habitat-derived radiomic features obtained during pretreatment ¹⁸F-fluorodeoxyglucose (FDG) positron emission tomography (PET) in patients with colorectal cancer (CRC).

Methods

We retrospectively enrolled 62 patients with CRC who had undergone ¹⁸F-FDG PET/computed tomography from January 2017 to July 2022 before the initiation of therapy. The patients were randomly split into training and validation cohorts with a ratio of 6:4. The whole tumor region radiomic features, habitat-derived radiomic features, and metabolic para

SUBMITTER: Zhao H 

PROVIDER: S-EPMC10860234 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature