Identification of candidate regulatory genes for intramuscular fatty acid composition in pigs by transcriptome analysis.

ABSTRACT:

Background

Intramuscular fat (IMF) content and its fatty acid (FA) composition are typically controlled by several genes, each with a small effect. In the current study, to pinpoint candidate genes and putative regulators involved in FA composition, we performed a multivariate integrative analysis between intramuscular FA and transcriptome profiles of porcine longissimus dorsi (LD) muscle. We also carried out a combination of network, regulatory impact factor (RIF), in silico prediction of putative target genes, and functional analyses to better support the biological relevance of our findings.

Results

For this purpose, we used LD RNA-Seq and intramuscular FA composition profiles of 129 Iberian × Duroc backcrossed pigs. We identified 378 correlated variables (13 FA and 365 g

SUBMITTER: Valdes-Hernandez J 

PROVIDER: S-EPMC10860264 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature