An atlas of cell-type-specific interactome networks across 44 human tumor types.

ABSTRACT:

Background

Biological processes are controlled by groups of genes acting in concert. Investigating gene-gene interactions within different cell types can help researchers understand the regulatory mechanisms behind human complex diseases, such as tumors.

Methods

We collected extensive single-cell RNA-seq data from tumors, involving 563 patients with 44 different tumor types. Through our analysis, we identified various cell types in tumors and created an atlas of different immune cell subsets across different tumor types. Using the SCINET method, we reconstructed interactome networks specific to different cell types. Diverse functional data was then integrated to gain biological insights into the networks, including somatic mutation patterns and gene functional annotation. Ad

SUBMITTER: Li Z 

PROVIDER: S-EPMC10860273 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature