Network pharmacology-based strategy to investigate the mechanisms of artemisinin in treating primary Sjogren's syndrome.

ABSTRACT:

Objective

The study aimed to explore the mechanism of artemisinin in treating primary Sjögren's syndrome (pSS) based on network pharmacology and experimental validation.

Methods

Relevant targets of the artemisinin and pSS-related targets were integrated by public databases online. An artemisinin-pSS network was constructed by Cytoscape. The genes of artemisinin regulating pSS were imported into STRING database to construct a protein-protein interaction (PPI) network in order to predict the key targets. The enrichment analyses were performed to predict the crucial mechanism and pathway of artemisinin against pSS. The active component of artemisinin underwent molecular docking with the key proteins. Artemisinin was administered intragastrically to SS-like NOD/Ltj mice to valid

SUBMITTER: Liao JH 

PROVIDER: S-EPMC10860289 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature