Bleeding assessment in a large cohort of patients with Osteogenesis Imperfecta.

ABSTRACT:

Background

Osteogenesis Imperfecta (OI) is characterised by bone fragility. Among several features, easy bruising and multiple case reports on haemorrhagic events have been reported. This paper describes the diverse manifestations of bleeding and bruising in a large cohort of 328 OI patients. The aim of this study is to provide insight in the diverse aspects and therapeutic considerations of bleedings in OI.

Methods

This descriptive cohort study was conducted at the National Expert Center for adults with OI in the Netherlands. Bleeding was assessed by the validated self-bleeding assessment tool (Self-BAT) The tool was distributed among 328 adults with different clinically confirmed types of OI.

Results

195 of 328 invited patients (completion rate 60%) with OI type 1 (

SUBMITTER: Gooijer K 

PROVIDER: S-EPMC10860322 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature