A robust evaluation of 49 high-dose-rate prostate brachytherapy treatment plans including all major uncertainties.

ABSTRACT:

Background

Uncertainties in radiotherapy cause deviation from the planned dose distribution and may result in delivering a treatment that fails to meet clinical objectives. The impact of uncertainties is unique to the patient anatomy and the needle locations in HDR prostate brachytherapy. Evaluating this impact during treatment planning is not common practice, relying on margins around the target or organs-at-risk to account for uncertainties.

Purpose

A robust evaluation framework for HDR prostate brachytherapy treatment plans was evaluated on 49 patient plans, measuring the range of possible dosimetric outcomes to the patient due to 14 major uncertainties.

Methods

Patient plans were evaluated for their robustness to uncertainties by simulating probable uncertainty sc

SUBMITTER: Kennedy AC 

PROVIDER: S-EPMC10860441 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature