Association of Traumatic Brain Injury with Late Life Neuropathological Outcomes in a Community-Based Cohort.

ABSTRACT:

Background

Prior studies into the association of head trauma with neuropathology have been limited by incomplete lifetime neurotrauma exposure characterization.

Objective

To investigate the neuropathological sequelae of traumatic brain injury (TBI) in an autopsy sample using three sources of TBI ascertainment, weighting findings to reflect associations in the larger, community-based cohort.

Methods

Self-reported head trauma with loss of consciousness (LOC) exposure was collected in biennial clinic visits from 780 older adults from the Adult Changes in Thought study who later died and donated their brain for research. Self-report data were supplemented with medical record abstraction, and, for 244 people, structured interviews on lifetime head trauma. Neuropathology ou

SUBMITTER: Gibbons LE 

PROVIDER: S-EPMC10860614 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature