Elucidating the evolution of monkeypox virus genomes through phylo-geo-network and haplogroup analysis.

ABSTRACT:

Background

As the world settles down from the COVID-19 pandemic, many countries are faced with an unexpected outbreak of monkeypox infection. Monkeypox is a zoonotic disease caused by monkeypox virus (MPXV), which is an enveloped, double stranded DNA virus belonging to the Poxviridae family. Presently, we construct and analyze the phylo-geo-network and the corresponding haplogroups. Presently, we performed the haplogroup analysis with their defining mutations and phylogenetic lineage study along with geographical distributions with the aim to understand the evolutionary path of the MPXV across the world.

Results

Information about 719 full length genomes of MPXV were collected from GISAID repository and the sequences extracted from NCBI. The alignment of 719 MPXV genomes and

SUBMITTER: Nasrin T 

PROVIDER: S-EPMC10860881 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature