Therapeutic interventions on human breast cancer xenografts promote systemic dissemination of oncogenes.

ABSTRACT: Metastatic dissemination following successful treatment of the primary tumour remains a common cause of death. There is mounting evidence that therapeutic interventions themselves may promote development of metastatic disease. We earlier reported that cell-free chromatin particles (cfChPs) released from dying cancer cells are potentially oncogenic. Based on this observation we hypothesized that therapeutic interventions may lead to the release of cfChPs from therapy induced dying cancer cells which could be carried via the blood stream to distant organs to transform healthy cells into new cancers that would masquerade as metastasis. To test this hypothesis, we generated xenografts of MDA-MB-231 human breast cancer cells in severe combined immune-deficient mice, and using immuno-fluorescenc

SUBMITTER: Raghuram GV 

PROVIDER: S-EPMC10861051 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature