Distinct cellular expression and subcellular localization of Kv2 voltage-gated K⁺ channel subtypes in dorsal root ganglion neurons conserved between mice and humans.

ABSTRACT: The distinct organization of Kv2 voltage-gated potassium channels on and near the cell body of brain neurons enables their regulation of action potentials and specialized membrane contact sites. Somatosensory neurons have a pseudounipolar morphology and transmit action potentials from peripheral nerve endings through axons that bifurcate to the spinal cord and the cell body within ganglia including the dorsal root ganglia (DRG). Kv2 channels regulate action potentials in somatosensory neurons, yet little is known about where Kv2 channels are located. Here, we define the cellular and subcellular localization of the Kv2 paralogs, Kv2.1 and Kv2.2, in DRG somatosensory neurons with a panel of antibodies, cell markers, and genetically modified mice. We find that relative to spinal cord neurons,

SUBMITTER: Stewart RG 

PROVIDER: S-EPMC10861167 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature