Endothelial cell-specific reduction in mTOR ameliorates age-related arterial and metabolic dysfunction.

ABSTRACT: Systemic inhibition of the mammalian target of rapamycin (mTOR) delays aging and many age-related conditions including arterial and metabolic dysfunction. However, the mechanisms and tissues involved in these beneficial effects remain largely unknown. Here, we demonstrate that activation of S6K, a downstream target of mTOR, is increased in arteries with advancing age, and that this occurs preferentially in the endothelium compared with the vascular smooth muscle. Induced endothelial cell-specific deletion of mTOR reduced protein expression by 60-70%. Although this did not significantly alter arterial and metabolic function in young mice, endothelial mTOR reduction reversed arterial stiffening and improved endothelium-dependent dilation (EDD) in old mice, indicating an improvement in age-re

SUBMITTER: Islam MT 

PROVIDER: S-EPMC10861194 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature