Pre-vaccination immunotypes reveal weak and robust antibody responders to influenza vaccination.

ABSTRACT: Effective vaccine-induced immune responses are particularly essential in older adults who face an increased risk of immunosenescence. However, the complexity and variability of the human immune system make predicting vaccine responsiveness challenging. To address this knowledge gap, our study aimed to characterize immune profiles that are predictive of vaccine responsiveness using "immunotypes" as an innovative approach. We analyzed an extensive set of innate and adaptive immune cell subsets in the whole blood of 307 individuals (aged 25-92) pre- and post-influenza vaccination which we associated with day 28 hemagglutination inhibition (HI) antibody titers. Building on our previous work that stratified individuals into nine immunotypes based on immune cell subsets, we identified two pre-va

SUBMITTER: Cevirgel A 

PROVIDER: S-EPMC10861208 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature