Animal protein hydrolysate reduces visceral fat and inhibits insulin resistance and hepatic steatosis in aged mice.

ABSTRACT:

Background/objectives

An increasing life expectancy in society has burdened healthcare systems substantially because of the rising prevalence of age-related metabolic diseases. This study compared the effects of animal protein hydrolysate (APH) and casein on metabolic diseases using aged mice.

Materials/methods

Eight-week-old and 50-week-old C57BL/6J mice were used as the non-aged (YC group) and aged controls (NC group), respectively. The aged mice were divided randomly into 3 groups (NC, low-APH [LP], and high-APH [HP] and fed each experimental diet for 12 weeks. In the LP and HP groups, casein in the AIN-93G diet was substituted with 16 kcal% and 24 kcal% APH, respectively. The mice were sacrificed when they were 63-week-old, and plasma and hepatic lipid, white adipose tis

SUBMITTER: Shin SK 

PROVIDER: S-EPMC10861341 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature