Exploration of differential responses to FODMAPs and gluten in people with irritable bowel syndrome- a double-blind randomized cross-over challenge study.

ABSTRACT:

Introduction

There is large variation in response to diet in irritable bowel syndrome (IBS) and determinants for differential response are poorly understood.

Objectives

Our aim was to investigate differential clinical and molecular responses to provocation with fermentable oligo-, di-, monosaccharides, and polyols (FODMAPs) and gluten in individuals with IBS.

Methods

Data were used from a crossover study with week-long interventions with either FODMAPs, gluten or placebo. The study also included a rapid provocation test. Molecular data consisted of fecal microbiota, short chain fatty acids, and untargeted plasma metabolomics. IBS symptoms were evaluated with the IBS severity scoring system. IBS symptoms were modelled against molecular and baseline questionnaire data,

SUBMITTER: Nordin E 

PROVIDER: S-EPMC10861383 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature