The causal effects of genetically predicted alcohol consumption on endometrial cancer risk from a Mendelian randomization study.

ABSTRACT: Endometrial cancer (EC) is a common gynecological tumor in females with an increasing incidence over the past few decades. Alcohol consumption has been linked to the occurrence of various cancers; However, epidemiological studies have shown inconsistent associations between alcohol consumption and EC risk. In order to avoid the influence of potential confounding factors and reverse causality in traditional epidemiological studies, we used a method based on genetic principles-Mendelian randomization (MR) analysis to test whether there is a causal relationship between alcohol consumption and EC. MR analysis was conducted using publicly available summary-level data from genome-wide association studies (GWAS). Fifty-seven single nucleotide polymorphisms (SNPs) were extracted as instrumental va

SUBMITTER: Yang J 

PROVIDER: S-EPMC10861519 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature