Disentangling the link between maternal influences on birth weight and disease risk in 36,211 genotyped mother-child pairs.

ABSTRACT: Epidemiological studies have robustly linked lower birth weight to later-life disease risks. These observations may reflect the adverse impact of intrauterine growth restriction on a child's health. However, causal evidence supporting such a mechanism in humans is largely lacking. Using Mendelian Randomization and 36,211 genotyped mother-child pairs from the FinnGen study, we assessed the relationship between intrauterine growth and five common health outcomes (coronary heart disease (CHD), hypertension, statin use, type 2 diabetes and cancer). We proxied intrauterine growth with polygenic scores for maternal effects on birth weight and took into account the transmission of genetic variants between a mother and a child in the analyses. We find limited evidence for contribution of normal va

SUBMITTER: Leinonen JT 

PROVIDER: S-EPMC10861556 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature