Relative synonymous codon usage and codon pair analysis of depression associated genes.

ABSTRACT: Depression negatively impacts mood, behavior, and mental and physical health. It is the third leading cause of suicides worldwide and leads to decreased quality of life. We examined 18 genes available at the genetic testing registry (GTR) from the National Center for Biotechnological Information to investigate molecular patterns present in depression-associated genes. Different genotypes and differential expression of the genes are responsible for ensuing depression. The present study, investigated codon pattern analysis, which might play imperative roles in modulating gene expression of depression-associated genes. Of the 18 genes, seven and two genes tended to up- and down-regulate, respectively, and, for the remaining genes, different genotypes, an outcome of SNPs were responsible alone

SUBMITTER: Khandia R 

PROVIDER: S-EPMC10861588 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature