Development of an adverse outcome pathway network for nephrotoxicity.

ABSTRACT: Adverse outcome pathways (AOPs) were introduced in modern toxicology to provide evidence-based representations of the events and processes involved in the progression of toxicological effects across varying levels of the biological organisation to better facilitate the safety assessment of chemicals. AOPs offer an opportunity to address knowledge gaps and help to identify novel therapeutic targets. They also aid in the selection and development of existing and new in vitro and in silico test methods for hazard identification and risk assessment of chemical compounds. However, many toxicological processes are too intricate to be captured in a single, linear AOP. As a result, AOP networks have been developed to aid in the comprehension and placement of associated events underlying the emerge

SUBMITTER: Barnes DA 

PROVIDER: S-EPMC10861692 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature