Guanylate binding protein 4 shapes an inflamed tumor microenvironment and identifies immuno-hot tumors.

ABSTRACT:

Purpose

Guanylate binding protein 4 (GBP4) is induced by interferons and various cytokines and has been recognized as functionally relevant in numerous types of human cancers. While the role of GBP4 in cancer has been preliminarily summarized, its correlation with antitumor immunity remains unclear and requires further research.

Methods

First, a comprehensive pan-cancer analysis was conducted, focusing on GBP4's expression patterns and immunological functions. Subsequently, we explored the correlations between GBP4 and immunological features within the tumor microenvironment (TME) in non-small cell lung cancer (NSCLC) patients. Additionally, we examined the relationships between GBP4 and emerging immunobiomarkers, such as N6-methyladenosine (m6A) genes. Moreover, we assessed

SUBMITTER: Zhou W 

PROVIDER: S-EPMC10861698 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature