Spitting in the wind?-The challenges of RNA sequencing for biomarker discovery from saliva.

ABSTRACT: Forensic trace contextualization, i.e., assessing information beyond who deposited a biological stain, has become an issue of great and steadily growing importance in forensic genetic casework and research. The human transcriptome encodes a wide variety of information and thus has received increasing interest for the identification of biomarkers for different aspects of forensic trace contextualization over the past years. Massively parallel sequencing of reverse-transcribed RNA ("RNA sequencing") has emerged as the gold standard technology to characterize the transcriptome in its entirety and identify RNA markers showing significant expression differences not only between different forensically relevant body fluids but also within a single body fluid between forensically relevant conditio

SUBMITTER: Gosch A 

PROVIDER: S-EPMC10861700 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature