Design of a targeted blood transcriptional panel for monitoring immunological changes accompanying pregnancy.

ABSTRACT:

Background

Immunomodulatory processes exert steering functions throughout pregnancy. Detecting diversions from this physiologic immune clock may help identify pregnant women at risk for pregnancy-associated complications. We present results from a data-driven selection process to develop a targeted panel of mRNAs that may prove effective in detecting pregnancies diverting from the norm.

Methods

Based on a de novo dataset from a resource-constrained setting and a dataset from a resource-rich area readily available in the public domain, whole blood gene expression profiles of uneventful pregnancies were captured at multiple time points during pregnancy. BloodGen3, a fixed blood transcriptional module repertoire, was employed to analyze and visualize gene expression patt

SUBMITTER: Brummaier T 

PROVIDER: S-EPMC10861739 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature