MCU promotes the migration of glioma cells by activating p38 through TFEB-mediated autophagy.
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ABSTRACT:
SUBMITTER: Chen J
PROVIDER: S-EPMC10861810 | biostudies-literature | 2024
REPOSITORIES: biostudies-literature
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MCU promotes the migration of glioma cells by activating p38 through TFEB-mediated autophagy.
Chen Jialong J Lu Renjian R Peng Yongming Y Lai Yixi Y Cai ZiWei Z Zheng Dongyan D Xie Ailan A Huang Kailun K Liang Congmin C Zhang He H
Journal of Cancer 20240112 5
Changes in calcium signalling are crucial for the development of glioma cells. Whether mitochondrial calcium balance is involved in glial cell development is still unknown. Mitochondrial Calcium Uniporter (MCU) plays an important role in regulating glioma progression. In this work, we found that MCU and p38 expression were positively correlated with glioma grade and the degree tumour progression. MCU increases glioma cell migration by upregulating p38. Furthermore, p38 promotes glioma progressio ...[more]
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