Local dose-dense chemotherapy for triple-negative breast cancer via minimally invasive implantation of 3D printed devices.

ABSTRACT: Dose-dense chemotherapy is the preferred first-line therapy for triple-negative breast cancer (TNBC), a highly aggressive disease with a poor prognosis. This treatment uses the same drug doses as conventional chemotherapy but with shorter dosing intervals, allowing for promising clinical outcomes with intensive treatment. However, the frequent systemic administration used for this treatment results in systemic toxicity and low patient compliance, limiting therapeutic efficacy and clinical benefit. Here, we report local dose-dense chemotherapy to treat TNBC by implanting 3D printed devices with time-programmed pulsatile release profiles. The implantable device can control the time between drug releases based on its internal microstructure design, which can be used to control dose density. T

SUBMITTER: Myung N 

PROVIDER: S-EPMC10861843 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature