Streamlined identification of clinically and functionally relevant genetic regulators of lower-tract urogenital development.

ABSTRACT: Congenital anomalies of the lower genitourinary (LGU) tract are frequently comorbid due to genetically linked developmental pathways, and are among the most common yet most socially stigmatized congenital phenotypes. Genes involved in sexual differentiation are prime candidates for developmental anomalies of multiple LGU organs, but insufficient prospective screening tools have prevented the rapid identification of causative genes. Androgen signaling is among the most influential modulators of LGU development. The present study uses SpDamID technology in vivo to generate a comprehensive map of the pathways actively regulated by the androgen receptor (AR) in the genitalia in the presence of the p300 coactivator, identifying wingless/integrated (WNT) signaling as a highly enriched AR-regulat

SUBMITTER: Haller M 

PROVIDER: S-EPMC10861909 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature