Maternal smoking around birth and its influence on offspring allergic diseases: A mendelian randomization study.

ABSTRACT:

Objective

The influence of maternal smoking around birth (MSAB) on offspring allergic diseases, specifically childhood asthma (CA), allergic rhinitis (AR), allergic conjunctivitis (AC), and atopic dermatitis (AD) remains incompletely understood. We performed a rigorous mendelian randomization (MR) study to obtain the unconfounded association between MSAB and allergic diseases in offspring with and without adjustment for the effect of breastfeeding.

Methods

Utilizing publicly available information of MSAB, breastfeeding, CA, AR, AC, and AD from large-scale genome-wide association studies (GWAS), we performed a two-sample mendelian randomization (TSMR) analysis to assess the respective causal relationship of MSAB and breastfeeding to allergic diseases in offspring. To get a re

SUBMITTER: Ruan Q 

PROVIDER: S-EPMC10862070 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature