Highly Effective Therapies as First-Line Treatment for Pediatric-Onset Multiple Sclerosis.

ABSTRACT:

Importance

Moderately effective therapies (METs) have been the main treatment in pediatric-onset multiple sclerosis (POMS) for years. Despite the expanding use of highly effective therapies (HETs), treatment strategies for POMS still lack consensus.

Objective

To assess the real-world association of HET as an index treatment compared with MET with disease activity.

Design, setting, and participants

This was a retrospective cohort study conducted from January 1, 2010, to December 8, 2022, until the last recorded visit. The median follow-up was 5.8 years. A total of 36 French MS centers participated in the Observatoire Français de la Sclérose en Plaques (OFSEP) cohort. Of the total participants in OFSEP, only treatment-naive children with relapsing-remitting POMS who rec

SUBMITTER: Benallegue N 

PROVIDER: S-EPMC10862269 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature