Insulin resistance prior to term age in very low birthweight infants: a prospective study.

ABSTRACT:

Objective

To explore the glucose-related hormone profile of very low birthweight (VLBW) infants and assess the association between neonatal hyperglycaemia and insulin resistance during the admission period.

Design

A prospective observational study-the Very Low Birth Weight Infants, Glucose and Hormonal Profiles over Time study.

Setting

A tertiary neonatal intensive care unit and four neonatal units in county hospitals in Sweden.

Patients

48 infants born <1500 g (VLBW) during 2016-2019.

Outcome measures

Plasma concentrations of glucose-related hormones and proteins (C-peptide, insulin, ghrelin, glucagon-like peptide 1 (GLP-1), glucagon, leptin, resistin and proinsulin), insulin:C-peptide and proinsulin:insulin ratios, Homoeostatic Model Assessment 2 (HOMA

SUBMITTER: Zamir I 

PROVIDER: S-EPMC10862284 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature