Analysis of Dopamine Receptor D2 Gene Polymorphism and Correlation with Dyslipidemia in the Chinese Population.

ABSTRACT:

Objective

The study aimed to explore the genotype and allele distributions of dopamine D2-like receptor (DRD2) gene -141C and C957T polymorphisms in the Chinese Han population with dyslipidemia, as well as their association with serum lipid levels.

Methods

One hundred fifty patients with dyslipidemia and 150 healthy people were recruited as the case and the control groups, respectively. Serum total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol levels were detected. The target sequence of DRD2 polymorphisms was amplified by polymerase chain reaction and genotyped via Sanger sequencing.

Results

In DRD2 gene C957T (rs6277), three genotypes of CC, CT, and TT were detected wit

SUBMITTER: Tan H 

PROVIDER: S-EPMC10862327 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature