Racial differences in measures of glycemia in the Vitamin D and Type 2 Diabetes (D2d) Study: a secondary analysis of a randomized trial.

ABSTRACT:

Introduction

Understanding how race may influence the association between A1c and glycemia can improve diabetes screening. We sought to determine whether, for a given A1c level, glucose levels during an oral glucose tolerance test (OGTT) differed by race.

Research design and methods

From data collected at 22 US clinical sites, we conducted a cross-sectional study of concurrently measured A1c and OGTT and observational longitudinal follow-up of the subset with high-risk pre-diabetes. Numerical integration methods were used to calculate area under the glycemic curve (AUC_glu) during OGTT and least squares regression model to estimate A1c for a given AUC_glu by race, controlling for potential confounders.

Results

1016 black, 2658 white, and 193 Asian

SUBMITTER: LeBlanc ES 

PROVIDER: S-EPMC10862329 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature