Can earlier BCG-Japan and OPV vaccination reduce early infant mortality? A cluster-randomised trial in Guinea-Bissau.

ABSTRACT:

Objective

To assess the effect of providing BCG and oral polio vaccine (OPV) at an early home visit after delivery.

Design

Cluster-randomised trial, randomising 92 geographically defined clusters 1:1 to intervention/control arms.

Setting

Bandim Health Project Health and Demographic Surveillance System, Guinea-Bissau.

Participants

2226 newborns enrolled between July 2016 and August 2019.

Interventions

In both arms, newborns received a home visit within 72 hours after birth. In intervention clusters (n=46), BCG and OPV were provided at the home visit.

Main outcome measure

Rates of non-accidental mortality were compared in Cox proportional hazards models from (last of) day 1 or enrolment, until (first of) day 60 or registration of non-trial vaccines.

SUBMITTER: Thysen SM 

PROVIDER: S-EPMC10862335 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature