R₂ Relaxometry of SABRE-Hyperpolarized Substrates at a Low Magnetic Field.

ABSTRACT: Nuclear magnetic resonance (NMR) relaxometry at a low magnetic field, in the milli-Tesla range or less, is enabled by signal enhancements through hyperpolarization. The parahydrogen-based method of signal amplification by reversible exchange (SABRE) provides large signals in a dilute liquid for the measurement of R₂ relaxation using a single-scan Carr-Purcell-Meiboom-Gill (CPMG) experiment. A comparison of relaxation rates obtained at high and low fields indicates that an otherwise dominant contribution from chemical exchange is excluded in this low-field range. The SABRE process itself is based on exchange between the free and polarization transfer catalyst-bound forms of the substrate. At a high magnetic field of 9.4 T, typical conditions for producing hyperpolarization

SUBMITTER: Pham P 

PROVIDER: S-EPMC10862376 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature