Low dose versus high dose stavudine for treating people with HIV infection.

ABSTRACT:

Background

Stavudine remains a component of combination antiretroviral therapy (ART) in resource-constrained countries due to its relatively low cost despite the WHO recommendation for its phasing out as a strategy to reduce stavudine associated toxicities. Where stavudine is still in use, it is recommended at a dose lower than the standard dose in order to reduce stavudine related toxicity.

Objectives

To compare the safety and virologic efficacy of low dose versus high dose stavudine for treating HIV-1 infection.

Search methods

The comprehensive search strategy developed by the Cochrane HIV/AIDS Review Group was used to identify randomised controlled trials that compared the use of low dose versus high dose stavudine. The last search was conducted in February 2014 an

SUBMITTER: Magula N 

PROVIDER: S-EPMC10862382 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature