Association of insertion /deletion polymorphism of ace gene with essential hypertension in patients of Khyber Pakhtunkhwa.

ABSTRACT:

Objective &background

The exact cause of hypertension is unknown in about 90 to 95% patients, known as essential hypertension. Genes may play a crucial role in the pathology of essential hypertension. Gene for angiotensin converting enzyme (ACE) is found on long arm of chromosome 17q23, where 287 base pair insertion or deletion (I/D) polymorphism may occur. This study was aimed to assess the association of I/D polymorphism of ACE gene with blood pressure (BP) in Patients of Khyber Pakhtunkhwa (KPK).

Methods

This Descriptive Cross-sectional study was conducted from 1^st June 2021 to 30^th September 2021 at Kuwait Teaching Hospital, Peshawar. The genomic DNA was extracted from lymphocytes and PCR was performed for identification of ACE I/D polymorphism.

SUBMITTER: Razaq A 

PROVIDER: S-EPMC10862427 | biostudies-literature | 2024 Jan-Feb

REPOSITORIES: biostudies-literature