Elucidation of the Role of Lipids in Late Endosomes on the Aggregation of Insulin.

ABSTRACT: Abrupt aggregation of misfolded proteins is the underlying molecular cause of numerous pathologies including diabetes type 2 and injection amyloidosis. Although the exact cause of this process is unclear, a growing body of evidence suggests that protein aggregation is linked to a high protein concentration and the presence of lipid membranes. Endosomes are cell organelles that often possess high concentrations of proteins due to their uptake from the extracellular space. However, the role of endosomes in amyloid pathologies remains unclear. In this study, we used a set of biophysical methods to determine the role of bis(monoacylglycero)phosphate (BMP), the major lipid constituent of late endosomes on the aggregation properties of insulin. We found that both saturated and unsaturated BMP ac

SUBMITTER: Joshi R 

PROVIDER: S-EPMC10862470 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature