LINC00960 affects osteosarcoma treatment and prognosis by regulating the tumor immune microenvironment.

ABSTRACT:

Background

Osteosarcoma (OS), the commonest primary malignant bone tumor, is mainly seen in children and teenagers. LINC00960, a newly discovered long intergenic non-protein coding RNA, has been shown to be important in certain cancers. The objective of this study was to assess LINC00960's prognostic and therapeutic value and analyze its mechanism of action in osteosarcoma.

Methods

With the transcriptome information of 85 osteosarcomas from the TARGET database, the Cox regression analyses, K-M curve, and ROC curve, were conducted for survival and prognostic analysis. The functional analysis was conducted using GO, KEGG, GSEA, and GSVA. The ESTIMATE, ssGSEA, MCP-counter, ImmuCellAI algorithms, and immune checkpoint correlation analysis were performed for immune-related analys

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC10862516 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature